Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models
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چکیده
منابع مشابه
Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models.
We attached the pathogen associated molecular pattern Kdo(2)-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo.
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The mortality of septic shock in the pediatric population has improved over the last 2 decades with better supportive care however it still remains unacceptably high. Exaggerated inflammatory responses early in septic shock have been associated with poor outcomes. Regulation of the magnitude of the early inflammatory response is not well understood. The earliest aspect of the inflammatory respo...
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ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2010
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c002066d